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Stephan Grein


location_icon   Endenicher Allee 64, 53115 Bonn, Germany

phone_icon   +49 (0)228 73 62246

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🔑︁   F598 BCFF 445C C90F 3312 3C71 7D30 C7E5 7559 76A6


Short CV

Stephan Grein has been working as a postdoctoral researcher at the LIMES institute since June 2021 focusing on metaflammation. Previous studies include Bioinformatics and obtaining a master's and bachelor's degree by Goethe-University in Frankfurt/Main. Lately he was awarded a Ph.D. degree in Applied Mathematics by Temple University, Philadelphia, PA in December 2020 working on the detailed modelling and simulation of intracellular ion-dynamics in neurons linked to synaptic plasticity and learning processes by developing novel hybrid-dimensional and multi-scale models as well as novel hierarchical mesh generation techniques for neurons applicable to multigrid methods for the efficient numerical simulation of the developed models on high-performance computing infrastructure. 

Research interests

numerical modeling and simulation, high performance computing, parallel programming, inflammation and cancer biology, synaptic plasticity and intracellular ion-dynamics, computational neuroscience, ODEs, PDEs, mixed-compute infrastructure (CPU/GPU)

Selected publications

  • (2021) C. Mertens, M. Schnetz, C. Rehwald, S. Grein, E. Elwakeel, A. Weigert, B. Brüne, M. Jung. Iron-Bound Lipocalin-2 from Tumor-Associated Macrophages Drives Breast Cancer Progression Independent of Ferroportin: Metabolites 18(3)
  • (2020) S. Grein, G. Qi, G. Queisser. Density Visualization Pipeline: A Tool for Cellular and Network Density Visualization and Analysis: Front Comput Neurosci. 14
  • (2020) Z. Li, A. Biswas, J. Finkelstein, S. Grein, Y. Kapoor, M. Milewski, G. Queisser. Modelling Drug Absorption from the Dermis after an Injection. Journal of Pharmaceutical Sciences 110(3)
  • (2017) C. Mertens, J. Mora, B. Ören, S. Grein, S. Winslow,  K. Scholich, A. Weigert, P. Malström, C. Forsare, M. Fernö, T. Schmidt, B. Brüne, M. Jung. Macrophage-derived lipocalin-2 transports iron in the tumor microenvironment: Oncoimmunology 7(3)
  • (2016) M. Breit, S. Stepniewski, S. Grein, P. Gottmann, L. Reinhardt, G. Queisser. Anatomically Detailed and Large-Scale Simulations Studying Synapse Loss and Synchrony Using NeuroBox:  Front Neuroanat. 10(8)
  • (2014) S. Grein, M. Stepniewski, S. Reiter, M.M. Knodel, G. Queisser: 1D-3D Hybrid Modelling - From Multi-Compartment Models to Full Resolution Models in Space and Time: Front Neuroinform. 8(68)

  • (2012) S. Wolf, S. Grein, G. Queisser. Employing NeuGen 2.0 to Automatically Generate Realistic Morphologies of Hippocampal Neurons and Neural Networks in 3D: Neuroinformatics 11(3)


  • (with Jan Hasenauer) Metaflammation and cellular programming in the SFB 1454